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Ketamine & Chronic Neuropathic Pain: Why the Diagnosis Matters

An educational overview of ketamine in selected chronic and neuropathic pain conditions and why diagnosis matters.

Ketamine is sometimes discussed for severe chronic or neuropathic pain, including conditions such as CRPS. Its role depends on the diagnosis, prior treatment, medical history and the goals of care.

Not all chronic pain is the same

Neuropathic pain, nociceptive pain and centralized pain can behave differently and may respond differently to treatment. A careful diagnosis helps determine whether ketamine is a reasonable option to discuss.

Where ketamine may fit

For selected patients, clinicians may consider ketamine as one component of a broader plan. Physical rehabilitation, medications, behavioral strategies and specialty care may remain important even when ketamine is used.

Set measurable goals

Useful goals can include changes in pain intensity, function, sleep or the ability to participate in rehabilitation. The treatment plan should be reassessed based on benefits, adverse effects and alternatives.

Important: This article is general education and does not establish that ketamine is appropriate for a particular pain diagnosis or patient.

Editorial note: Medical content should be reviewed by a licensed clinician before publication and updated as evidence or guidance changes.

Have questions about ketamine therapy?

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